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Hideyuki Okano Selected Research

RNA-Binding Proteins (RNA-Binding Protein)

5/2022Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.
11/2021NEAT1 lncRNA and amyotrophic lateral sclerosis.
1/2020Analysis of the nucleocytoplasmic shuttling RNA-binding protein HNRNPU using optimized HITS-CLIP method.
1/2017Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes.
12/2016RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins.
7/2013The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.
9/2012Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.
4/2012Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions.
1/2012RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
4/2010Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.
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Hideyuki Okano Research Topics

Disease

72Spinal Cord Injuries (Spinal Cord Injury)
11/2022 - 03/2004
42Neoplasms (Cancer)
01/2022 - 10/2004
19Parkinson Disease (Parkinson's Disease)
01/2021 - 10/2002
16Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 06/2002
14Ischemia
10/2018 - 03/2002
13Brain Ischemia (Cerebral Ischemia)
10/2013 - 05/2003
12Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
05/2022 - 01/2006
11Inflammation (Inflammations)
09/2015 - 05/2003
10Stroke (Strokes)
10/2018 - 10/2004
8Alzheimer Disease (Alzheimer's Disease)
01/2022 - 10/2006
8Hearing Loss (Hearing Impairment)
11/2021 - 04/2010
8Carcinogenesis
01/2020 - 04/2002
7Glioma (Gliomas)
09/2022 - 04/2005
7Glioblastoma (Glioblastoma Multiforme)
01/2020 - 05/2011
7Hypertension (High Blood Pressure)
01/2019 - 04/2005
7Hypoxia (Hypoxemia)
01/2017 - 05/2010
6Schizophrenia (Dementia Praecox)
11/2021 - 01/2014
6Infarction (Infarctions)
10/2018 - 06/2005
6Gliosis
01/2017 - 06/2005
6Teratoma (Teratoid Tumor)
01/2013 - 10/2009
5Brain Neoplasms (Brain Tumor)
09/2022 - 04/2005
5Mitochondrial Diseases (Mitochondrial Disease)
01/2021 - 10/2012
5Neurodevelopmental Disorders
01/2020 - 05/2015
5Demyelinating Diseases (Demyelinating Disease)
10/2018 - 08/2003
4Sensorineural Hearing Loss
06/2022 - 01/2012
4Sarcoma (Soft Tissue Sarcoma)
11/2021 - 07/2013
4Epilepsy (Aura)
01/2021 - 01/2010
4Autistic Disorder (Autism)
01/2020 - 07/2015
4Hyperalgesia
11/2018 - 01/2011
4Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/2018 - 06/2005
4Wounds and Injuries (Trauma)
01/2017 - 03/2005
4Central Nervous System Diseases (CNS Diseases)
09/2016 - 01/2008
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013 - 11/2006
4Nervous System Diseases (Neurological Disorders)
09/2012 - 02/2009
3Atrophy
11/2021 - 03/2013
3Cerebral Infarction
01/2020 - 02/2006
3Breast Neoplasms (Breast Cancer)
07/2018 - 08/2010
3Brain Diseases (Brain Disorder)
01/2018 - 07/2015
3Melanoma (Melanoma, Malignant)
10/2017 - 01/2013
3Cicatrix (Scar)
01/2017 - 12/2005
3Neoplasm Metastasis (Metastasis)
01/2017 - 06/2012
3Fibrosis (Cirrhosis)
01/2016 - 10/2007
3Neuralgia (Stump Neuralgia)
09/2015 - 03/2013
2Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
05/2022 - 01/2017

Drug/Important Bio-Agent (IBA)

31Proteins (Proteins, Gene)FDA Link
01/2022 - 04/2002
16RNA-Binding Proteins (RNA-Binding Protein)IBA
05/2022 - 04/2002
15Pharmaceutical PreparationsIBA
06/2022 - 10/2009
10CytokinesIBA
04/2010 - 08/2003
9NestinIBA
04/2018 - 09/2002
9Interleukin-6 (Interleukin 6)IBA
01/2014 - 06/2005
7Biological ProductsIBA
01/2020 - 04/2008
7Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2020 - 08/2007
7salicylhydroxamic acid (SHAM)IBA
01/2018 - 03/2002
6Retinaldehyde (Retinal)IBA
01/2021 - 12/2006
6SynucleinsIBA
01/2021 - 01/2012
6Messenger RNA (mRNA)IBA
01/2020 - 04/2002
6Bromodeoxyuridine (BrdU)IBA
11/2005 - 03/2002
5DNA (Deoxyribonucleic Acid)IBA
11/2021 - 09/2005
5RNA (Ribonucleic Acid)IBA
01/2020 - 05/2016
5Biomarkers (Surrogate Marker)IBA
01/2020 - 07/2015
5Transcription Factors (Transcription Factor)IBA
01/2017 - 09/2005
4Therapeutic UsesIBA
11/2022 - 12/2006
4Semaphorin-3AIBA
01/2021 - 12/2006
4Phosphotransferases (Kinase)IBA
12/2020 - 03/2013
4Indicators and Reagents (Reagents)IBA
05/2020 - 06/2003
4Galectin 1 (LGALS1)IBA
07/2012 - 10/2007
4Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
08/2010 - 06/2005
4Granulocyte Colony-Stimulating Factor (G-CSF)IBA
11/2007 - 12/2004
4InterleukinsIBA
06/2007 - 06/2005
3Apolipoproteins E (ApoE)IBA
01/2022 - 12/2017
3Amyloid (Amyloid Fibrils)IBA
01/2022 - 01/2020
3gamma-Aminobutyric Acid (GABA)IBA
11/2021 - 01/2010
3polyglutamineIBA
06/2021 - 03/2013
3MicroRNAs (MicroRNA)IBA
01/2021 - 01/2012
3Androgen Receptors (Androgen Receptor)IBA
01/2020 - 03/2013
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
12/2018 - 01/2013
3Glial Fibrillary Acidic ProteinIBA
10/2018 - 04/2010
3Oxygen (Dioxygen)IBA
10/2018 - 03/2012
3ChromatinIBA
11/2017 - 06/2008
3UbiquitinIBA
01/2017 - 09/2008
3Protein Isoforms (Isoforms)IBA
01/2017 - 10/2003
3Chondroitin ABC LyaseIBA
12/2016 - 12/2005
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
09/2015 - 07/2005
3Small Interfering RNA (siRNA)IBA
06/2012 - 05/2011
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2012 - 06/2007
3SynaptophysinIBA
01/2011 - 12/2006
3Rhodopsin (Visual Purple)IBA
01/2011 - 12/2006
3Nerve Growth Factors (Neurotrophins)IBA
01/2011 - 01/2006
3Type 1 Angiotensin ReceptorIBA
01/2011 - 12/2006
3Green Fluorescent ProteinsIBA
05/2010 - 02/2006
3Nicardipine (Dagan)FDA LinkGeneric
01/2006 - 09/2005
2Peptides (Polypeptides)IBA
01/2022 - 09/2020

Therapy/Procedure

56Therapeutics
11/2022 - 10/2002
52Transplantation
11/2022 - 10/2002
8Cell- and Tissue-Based Therapy (Cell Therapy)
01/2021 - 04/2008
5Cell Transplantation
11/2021 - 01/2007
5Stem Cell Transplantation
01/2019 - 01/2006
4Drug Therapy (Chemotherapy)
01/2021 - 05/2008
3Catheters
07/2014 - 11/2005
3Injections
01/2012 - 01/2007